Doxycycline online in Australia

What is Doxycycline used for?

They arise both from the antibacterial activity and from the pharmacokinetic properties of doxycycline.

· Indications that take into account both the situation of this antibiotic in the range of antibacterial products currently available and updated knowledge on the resistance of bacterial species. They are limited to the following infections:

or brucellosis,

or pasteurellosis,

o Lung, genitourinary, and ophthalmic chlamydia infections.

or pulmonary, genitourinary infections with mycoplasmas,

or rickettsiosis

or Coxiella burnetii (Q fever),

or gonococcal disease,

o ENT and bronchopulmonary infections with Haemophilus influenzae, in particular acute exacerbations of chronic bronchitis,

or treponemes, (in syphilis, tetracyclines are only indicated in case of allergy to beta-lactams),

or spirochetes (Lyme disease, leptospirosis),

or anger,

o moderate and severe inflammatory acne and inflammatory component of mixed acne.

Rosacea in its cutaneous or ocular manifestations.

Special situations

Prophylactic treatment after exposure and curative treatment of anthrax.

Official recommendations on the proper use of antibacterials should be taken into account.

Conditions for which this medicine may be prescribed

• Brucellosis
• Pasteurellosis
• Lung Chlamydia Infection
• Chlamydial genitourinary infection
• Chlamydia ophthalmic infection
• Pulmonary mycoplasma infection
• Genitourinary Mycoplasma Infection
• Rickettsiosis
• Q fever
• Gonococcal disease
• Haemophilus influenzae ENT infection
• Haemophilus influenzae bronchopulmonary infection
• Treponemal infection
• Spirochete infection
• Anger
• The acne
• Rosacea of skin or eye
• Anthrax

Method of administration and dosage of the drug Doxycycline

Dose

Adults

· Subjects weighing more than 60 kg.

200 mg per day in one shot

· Subjects weighing less than 60 kg.

200 mg the first day

100 mg the following days in one dose

Specific cases:

Acute gonorrhea

or adult man

§ 300 mg the first day (in 2 divided doses) followed by 200 mg per day for 2 to 4 days

§ or one minute treatment of 500 mg or 2 doses of 300 mg administered 1 hour apart

or adult women

§ 200 mg per day

· Primary and secondary syphilis.

or 300 mg per day in 3 doses for at least 10 days

Uncomplicated urethritis, endocervicitis, proctitis due to Chlamydiae trachomatis

or 200 mg per day for at least 10 days

The acne

or 100 mg per day for at least 3 months. In some cases, half-dose therapy can be used

Rosacea in its cutaneous or ocular manifestations.

or 100 mg per day for 3 months. There are no clinical data available after three months of treatment.

Special situations:

Anthrax: post-exposure prophylaxis and curative treatment for symptomatic persons who can receive oral treatment, either immediately or in combination with parenteral treatment: 200 mg / day in two divided doses. The duration of treatment is 8 weeks when exposure to anthrax is tested.

Pediatric population

Children from 12 to less than 18 years old.

The recommended dose of doxycycline for the treatment of acute infections in children aged 12 years to less than 18 years is 200 mg on the first day (in one or more doses) followed by a maintenance dose of 100 mg / day. In the case of more severe infection treatment, 200 mg per day should be administered for the duration of treatment.

Children from 8 years to less than 12 years (see section Warnings and precautions for use)

The use of doxycycline for the treatment of acute infections in children aged 8 years to less than 12 years should be duly justified in situations where other medicines are not available, are contraindicated or are effective. unlikely.

In these cases, the doses for the treatment of acute infections are:

Children 45 kg or less - starting dose: 4.4 mg / kg (in one or 2 separate doses) with a maintenance dose of 2.2 mg / kg (in a single dose or 2 fractions of the dose) For the treatment of infections more severe, a dose of up to 4.4 mg / kg should be administered for the duration of treatment.

· Children over 45 kg: use the same dose as that given to adults.

Children from birth to less than 8 years.

Doxycycline should not be used in children younger than 8 years due to the risk of discolored teeth (see sections 4.4 and 4.8).

Special situations

Anthrax: post-exposure prophylaxis and curative treatment of symptomatic persons who can receive oral treatment, either immediately or in combination with parenteral treatment: 4 mg / kg / day in two divided doses without exceeding the adult dose (200 mg / day).

The duration of treatment is 8 weeks when exposure to anthrax is tested.

Administration form

Administer in the middle of a meal with a glass of water (100 ml) and at least one hour before going to bed.

Possible side effects of Doxycycline

• Photosensitization reaction
• Acne
• Erythroderma
• Photoonicolysis
• Hyperpigmentation
• Allergic reaction
• Allergic urticaria
• Skin itching
• Angioedema
• Anaphylactic reaction
• Rheumatoid purple
• Pericarditis
• Exacerbation of lupus erythematosus
• Herxheimer reaction
• Intracranial hypertension
• Dental dyschromia
• Enamel hypoplasia
• Digestive disorder
• Sickness
• Epigastralgia
• Diarrhea
• Anorexy
• Gloss
• Enterocolitis
• Anogenital candidiasis
• Dysphagia
• Esophagitis
• Esophageal ulceration
• Hemolytic anemia
• Thrombocytopenia
• Neutropenia
• Eosinophilia
• Laxative effect
• Stomach ache

Show more Skin and subcutaneous tissue disorders.

Photosensitization reactions, skin rash, very rare cases of erythroderma, photoonicolysis, cases of hyperpigmentation.

Kidney and urinary tract disorders.

Extrarenal hyperazotemia related to an anti-anabolic effect and which can be increased by association with diuretics has been reported with tetracyclines. This hyperazotemia has not been observed to date with doxycycline.

Immune system disorders.

Allergic reactions (urticaria, rash, pruritus, angioedema, anaphylactic reaction, rheumatoid purpura, pericarditis, exacerbation of pre-existing lupus erythematosus).

Frequency "not known": Jarisch-Herxheimer reaction (see Warnings and Precautions section)

Nervous system disorders

Mild intracranial hypertension has been reported in adults during treatment with tetracyclines. Therefore, treatment should be discontinued if increased intracranial pressure is suspected or observed during treatment with doxycycline.

Gastrointestinal disorders.

Nausea / vomiting, dyspepsia (heartburn / gastritis), pancreatitis, pseudomembranous colitis, C. difficile colitis, esophageal ulcer, esophagitis, diarrhea, glossitis, enterocolitis, inflammatory lesions in the anogenital region, dysphagiea, abdominal pain, dental discoloration or hypoplasia by email b.

Possible appearance of dysphagia, esophagitis, esophageal ulcerations, favored by taking it in a supine position and / or with a small amount of water.

b Reversible and superficial discoloration of permanent teeth has been reported with the use of doxycycline, but the frequency cannot be estimated from the available data.

Blood and lymphatic system disorders.

Cases of hematological disorders have been described during treatment with tetracyclines (hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia).

Contraindications: when not to use this medicine?

• Doxycycline hypersensitivity
• Tetracycline hypersensitivity
• Hypersensitivity to castor oil
• Child under 8
• Pregnancy from the second trimester.
• Sun exposure
• Exposure to UV rays
• Breastfeeding
• First trimester pregnancy

Show more · hypersensitivity to the active substance or to any of the excipients included in the Composition or to antibiotics of the tetracycline family,

In children under eight years of age due to the risk of permanent discoloration of the teeth and hypoplasia of the dental enamel, except in the case of serious or life-threatening diseases when the expected benefits outweigh the risks, and only in the absence of suitable therapeutic alternatives (see section Warnings and precautions for use),

In combination with general retinoids (see section Interactions with other medicinal products and other forms of interaction),

· In case of pregnancy: Doxycycline is contraindicated in case of pregnancy. It appears that the risks associated with taking tetracyclines during pregnancy are primarily due to effects on dental and bone development (see section 4.4).

· In lactation: Tetracyclines are excreted in breast milk and are therefore contraindicated in lactating women (see section Warnings and precautions for use related to dental development).

Presentation of this medicine

Tablets in blister, box of 5, 10, 15, 20, 30 and 100.

Appearance and shape

Annotated tablet

Doxycycline: its other forms

• Doxycycline 100 mg, scored tablet, box of 5
• Doxycycline 100 mg, scored tablet, box of 30

Composition of the drug Doxycycline

* per unit dose Active ingredients: Doxycycline Diluents with known effects? : Hydrogenated castor oil Other excipients: Microcrystalline cellulose, Carboxymethyl sodium starch, Povidone, Colloidal anhydrous silica, Magnesium stearate Effects on ability to drive and use machines

Aimlessly.

Warnings and precautions for use

• Erythema of the skin
• Increased intracranial pressure

Due to the risks of photosensitization, it is advisable to avoid any direct exposure to the sun and UV rays during treatment, which should be interrupted in the event of skin manifestations such as erythema.

Due to the risks of esophageal damage, it is important to ensure compliance with the administration conditions (see sections 4.2 and 4.8).

This medicine contains castor oil and can cause digestive disorders (mild laxative effect, diarrhea).

Some patients with spirochetal infections may experience a Jarisch-Herxheimer reaction shortly after starting doxycycline treatment. Patients should be reassured by informing them that this is a generally spontaneous consequence of antibiotic treatment of spirochetal infections.

This medicine contains less than 1 mmol (23 mg) sodium per tablet, meaning that it is essentially "sodium free".

Pediatric population

The use of drugs of the tetracycline class during dental development (last half of pregnancy; during infancy and childhood up to the age of 8 years) can cause permanent discoloration of the teeth (yellow-gray-brown). This side effect is more common with long-term use of these medications, but has been observed after repeated short-term treatments. Hypoplasia of tooth enamel has also been reported. The use of doxycycline is possible in pediatric patients under the age of 8 years, only in the case of serious or life-threatening diseases when the expected benefits outweigh the risks and only in the absence of suitable therapeutic alternatives.

Although the risk of permanent tooth discoloration is rare in children aged 8 to less than 12 years, the use of doxycycline should be duly justified in situations where other medications are not available, are contraindicated, or whose effectiveness is unlikely.

Mechanism of action: how does it work?

Pharmacotherapeutic group: Antibacterials for systemic use, ATC code: J01AA02.

Doxycycline is an antibiotic in the tetracycline family. Inhibits the protein synthesis of bacteria.

Doxycycline increases sebaceous excretion, has an anti-inflammatory and anti-lipase action.

SPECTRUM OF ANTIBACTERIAL ACTIVITY

Critical concentrations separate the sensitive strains from the intermediate and the last resistant strains:

S ≤ 4 mg / l and R plus 8 mg / l

The prevalence of acquired resistance may vary by geography and time for some species. Therefore, it is useful to have information on the prevalence of local resistance, especially for the treatment of serious infections. These data can only provide guidance on the probabilities of the sensitivity of a bacterial strain to this antibiotic.

When the variability in the prevalence of resistance in Australia is known for a bacterial species, it is indicated in the table below:

* The frequency of methicillin resistance is approximately 30 to 50% of all staphylococci and is found mainly in hospitals.

** Bacillus anthracis: A study on an experimental model of anthrax infection, performed by inhalation of Bacillus anthracis spores in the Rhesus monkey, shows that antibiotic therapy started early after exposure, prevents the onset of disease if treatment is continued until the amount of persistent spores in the body falls below the infectious dose.

Interactions: do not take this medicine with ..

Contraindicated associations

+ Retinoids (general route)

Intracranial hypertension risk.

Associations subject to precautions for use.

+ Enzyme inducing anticonvulsants

Decreased plasma concentrations of doxycycline by increasing your liver metabolism.

Clinical monitoring and possible adaptation of the dose of doxycycline.

+ Didanosine

Decreased digestive absorption of cyclins due to increased gastric pH (presence of an antacid in the DDI tablet). Take didanosine away from cyclins (more than 2 hours, if possible).

+ Iron salts, oral

Decreased digestive absorption of cyclins (complex formation).

Remove iron salts from cyclins (more than 2 hours, if possible).

+ Gastrointestinal topics (salts, oxides, magnesium, aluminum and calcium hydroxides)

Decreased digestive absorption of cyclins.

Remove gastrointestinal topics from cyclins (more than 2 hours, if possible).

+ Oral anticoagulants

Increased oral anticoagulant effect and risk of bleeding.

More frequent monitoring of the prothrombin level and monitoring of the INR. Possible dose adjustment of oral anticoagulant during and after discontinuation of cyclin treatment.

Associations to consider

+ Zinc salts

Decreased digestive absorption of cyclins.

Remove zinc salts from cyclins (more than 2 hours if possible).

+ Special INR imbalance problems

Many cases of increased oral anticoagulant activity have been reported in patients receiving antibiotics. The marked infectious or inflammatory context, the age and the general condition of the patient seem to be risk factors. In these circumstances, it seems difficult to draw a line between infectious pathology and its treatment in the appearance of INR imbalance. However, certain classes of antibiotics are more involved: these include fluoroquinolones, macrolides, cyclins, cotrimoxazole, and certain cephalosporins.

Incompatibilities

Aimlessly.

How to react in case of overdose?

No overdose accidents have been reported. Those reported for other tetracyclines are unlikely to occur with doxycycline as a result of renal impairment (liver toxicity, hyperazotemia, hyperphosphatemia, acidosis) due to unchanged blood levels based on the functional value of the kidney.

Doxycycline: pregnancy, lactation and fertility

Pregnancy

Animal studies have not shown any teratogenic effects. In the absence of a teratogenic effect in animals, a malformation effect is not expected in the human species. In fact, to date, the substances responsible for malformations in the human species have been shown to be teratogenic in animals during well-conducted studies in two species.

In clinical practice, the use of cyclins during a limited number of pregnancies has apparently not revealed any particular malformation effects to date. However, additional studies are needed to assess the consequences of exposure during pregnancy.

Cyclin administration during the second and third trimesters exposes the fetus to the risk of staining baby teeth.

Therefore, as a precaution, it is best not to use cyclins during the first trimester of pregnancy.

From the second trimester of pregnancy, the administration of cyclins is contraindicated.

Breastfeeding

Breastfeeding is not recommended during treatment with this medicine.