Synthroid online in Australia

What is Synthroid used for?

Hypothyroidism

· Circumstances, associated or not with hypothyroidism, where it is necessary to decrease TSH.

Conditions for which this medicine may be prescribed

• Hypothyroidism
• When it is necessary to stop TSH

Method of administration and dosage of the drug Synthroid

Hypothyroidism

The doses administered vary according to the degree of hypothyroidism, the age of the patient and individual tolerance. Since hypothyroidism is in most cases a definitive disease, treatment should be continued indefinitely.

In adults:

In general, hormone replacement therapy requires an average of 100 to 150 µg in a single dose in the morning on an empty stomach.

This dose should be established gradually, starting, for example, with 25 µg per day; the daily dose will be increased by 25 µg in steps of approximately one week.

More progressive dosing regimens may also be proposed, particularly in cases of heart or coronary insufficiency, arrhythmia, and in the elderly, where it is advisable to start treatment with lower doses and adhere to higher levels. progressive

In acute postoperative hypothyroidism in the absence of underlying cardiac pathology, treatment may be started from the start at 1 µg / kg / day as a single substitution and at 2 µg / kg / day as restriction therapy (dose adjustment from so).

The average doses are 1.7 µg / kg / day for replacement treatments and 2.1 to 2.5 µg / kg / day for restriction treatments.

In combination with synthetic antithyroid drugs in the treatment of Graves' disease, the dose is 25 to 125 µg to adapt to the biological results.

In all cases, the dose should be adjusted according to the results of TSH, associated with free T4 after approximately 5 weeks of taking the constant dose (at least). Monitoring of the patient will be carried out in the clinic, looking for signs of overdose (nervousness, tachycardia, insomnia) and in biology. In balance, if the clinical condition is stable, a dose once or twice a year is sufficient.

In children:

This treatment is reserved for children who can take tablets.

The dose is 100 µg per m2 of body surface area per day (the dose should not exceed 50 to 100 µg / day) and should be adapted according to biological results.

Possible side effects of the drug Synthroid

• Worsening of heart disease.
• Tachycardia
• Shaking
• Rhythm disturbances
• Insomnia
• Excitability
• Temperature increase
• Sweat
• Rapid weight loss
• Diarrhea
• Hypercalciuria
• Allergic reaction

Show more · Worsening of any heart disease (heart failure, angina, rhythm disturbances ...).

Signs of hyperthyroidism, such as tachycardia, tremors, heart rhythm disturbances, insomnia, excitability, increased temperature, sweating, rapid weight loss, diarrhea, should make the practice a hormonal dose, reduce or stop the treatment that will be then it was resumed at lower doses.

· In children, possibility of hypercalciuria.

In case of hypersensitivity, allergic reactions may appear.

Contraindications: when not to use this medicine?

• Levothyroxine hypersensitivity
• Hyperthyroidism, except when reduced with antithyroid drugs, iodine 131, or surgery
• Child unable to swallow tablets
• Decompensated heart disease
• Uncontrolled coronary heart disease
• Alterations of the uncontrolled rhythm.

· Child unable to swallow tablets.

Hypersensitivity to one of the constituents,

Hyperthyroidism, except when this has been reduced with antithyroid drugs, iodine 131, or surgery (for example, in the case of long-term treatment of Graves' disease with the combination of synthetic antithyroids + levothyroxine).

This medication is generally not recommended for decompensated heart disease, coronary artery disease, and uncontrolled rhythm disturbances.

Presentation of this medicine

30 tablets in blister (PVC / PVDC / Aluminum).

Appearance and shape

White scored tablet.

Synthroid: its other forms

• Synthroid 25 micrograms, scored tablet, box of 28
• Synthroid 50 micrograms, scored tablet, box of 28
• Synthroid 75 micrograms, scored tablet, box of 28
• Synthroid 100 micrograms, scored tablet, box of 28
• Synthroid 125 micrograms, scored tablet, box of 28
• Synthroid 200 micrograms, scored tablet, box of 30
• Synthroid 125 micrograms, scored tablet, box of 30
• Synthroid 175 micrograms, scored tablet, box of 30
• Synthroid 150 micrograms, scored tablet, box of 28
• Synthroid 175 micrograms, scored tablet, box of 28
• Synthroid 200 micrograms, scored tablet, box of 28
• Synthroid 100 micrograms, scored tablet, box of 30
• Synthroid 75 micrograms, scored tablet, box of 30
• Synthroid 150 micrograms, scored tablet, box of 30
• Synthroid 50 micrograms, scored tablet, box of 30
• Synthroid 25 micrograms, scored tablet, box of 90
• Synthroid 50 micrograms, scored tablet, box of 90

View all forms of the drugComposition of the drug Synthroid

* per unit dose Active ingredients: levothyroxine sodium Excipients: microcrystalline cellulose, hypromellose, magnesium stearate, mannitol No excipient with known effect? not present in the composition of this medicine

Effects on ability to drive and use machines

Aimlessly.

Warnings and precautions for use

• Obesity without hypothyroidism.
• TSH monitoring
• Cardiac pathology
• Pituitary hypothyroidism
• Pregnancy

Special warnings

Obesity without hypothyroidism is not an indication of thyroid hormones used alone or in combination. Its administration in large doses or in combination with amphetamine substances can be dangerous.

The effectiveness of the treatment and any signs of intolerance only appear after a delay of around 15 days to a month.

Employment precautions

The quality of the therapeutic balance should be verified by means of an adequate endocrinological evaluation.

In the case of cardiac pathology balanced by treatment (coronary disorders, arrhythmias), the indication should be discussed on a case-by-case basis. If treatment is instituted, substitution is limited to obtaining a TSH at high normal values. Special attention should be paid to the monitoring of subjects.

If there is a risk of adrenocortical insufficiency (particularly in cases of hypothyroidism of pituitary origin), treatment with hydrocortisone should be instituted in advance.

Mechanism of action: how does it work?

LEVOTHYROXIN SODIUM.

(H03AA01: Thyroid Drugs).

The thyroid hormone, chemically defined in its natural form L, is more active than the D form. Levothyroxine essentially increases tissue oxygen consumption, basic metabolism, and heart rate.

Interactions: do not take this medicine with ..

Associations subject to precautions for use.

+ Oral anticoagulants

Increased effect of the oral anticoagulant and risk of bleeding (increased metabolism of prothrombic complex factors).

More frequent monitoring of prothrombin and INR levels is required.

Adaptation of the oral anticoagulant dose when starting treatment for hypothyroidism or thyroid hormone overdose.

However, such special monitoring is not necessary in patients with stable thyroid replacement therapy.

+ Cholestyramine

Decreased activity of thyroid hormones (reduced intestinal absorption). Take cholestyramine away from thyroid hormones (more than 2 hours if possible).

+ Enzyme inducers

Anticonvulsants (carbamazepine, phenobarbital, phenytoin, primidone, barbiturates); griseofulvin; rifampin

Described for phenytoin, rifampin, and carbamazepine.

Risk of clinical hypothyroidism in patients with hypothyroidism when combined with increased metabolism of T3 and T4.

Monitoring of serum T3 and T4 levels and adaptation, if necessary, of the thyroid hormone dose during and after treatment with the enzyme inducer.

+ Iron (salts) by mouth

Decreased digestive absorption of levothyroxine and hypothyroxinemia. Remove levothyroxine from these products (more than 2 hours, if possible).

+ Kayexalate, sucrafalte, gastrointestinal topics

Decreased digestive absorption of levothyroxine. Remove levothyroxine from these products (more than 2 hours, if possible).

+ Chloroquine / proguanil

Risk of clinical hypothyroidism in patients substituted with thyroid hormones.

Monitoring of serum TSH and T3 and T4 concentrations and adjustment, if necessary, of the dose of thyroid hormones during treatment with antimalarials and after discontinuation.

Association to consider

+ Non-contraceptive estrogens

Possible need to increase levothyroxine doses in postmenopausal women on estrogen replacement therapy.

Incompatibilities

Aimlessly.

How to react in case of overdose?

It is, in general, an acute poisoning that includes the image of the thyrotoxic crisis, which can be limited to tachycardia according to the dose and that occurs between the 3rd and 5th day. In this case, it is necessary to suspend the treatment for a few days.

Treatment: beta-blockers, sedatives.

Synthroid: pregnancy, lactation and fertility

Pregnancy

Levothyroxine passes very little through the placenta and its administration has no fetal consequences.

Thyroid hormone treatment should be continued throughout the pregnancy.

It is recommended to reinforce clinical and biological surveillance, more particularly in early pregnancy, and adapt treatment if necessary.

Breastfeeding

Breastfeeding is possible during treatment with thyroid hormones.

You can read our articles:

• Frequently asked questions about diagnosing hypothyroidism
• Home remedy for hypothyroidism to effectively control the tsh level
• How to treat hypothyroidism
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• Naked facts about the symptoms and treatment of hypothyroidism
• Suggestions for a hypothyroid diet
• The hidden cause of hypothyroidism
• Treatment of subclinical hypothyroidism
• Use effective home remedies for hypothyroidism